Physical encoding based bioinformatics analysis for ezploring protein sorting signals

摘要：

BackgroundProtein sorting is the mechanism used by the cell to transport proteins to the appropriate locations within or outside the cell. With rapid accumulation of protein signal peptides and protein localization data1, bioinformatics algorithms have been developed to predict protein targeting signals and protein localizations. Here we apply a physical encoding method combined with localization classification to analyze the structures of sorting signals targeting different subcellular locations.Data & MethodsWe developed an amino acid index based physical encoding for localization prediction and applied to a reduced non-redundant protein sequence set used by Bacello algorithm for comparing protein localization predictors 2.

作者: Fan Zhang Jianjun Hu

作者单位: Department of Computer Science and Engineering, University of South Carolina, Columbia, 29208, USA

会议类型: 国际会议

会议名称: The 7th Asia-Pacific Bioinformatics Conference(第七届亚太生物信息学大会)

会议地点: 北京

会议语种:英文

页码: 883

在线出版日期: 2009-01-01（万方平台首次上网日期，不代表论文的发表时间）