Identification of disease genes via network alignment of human interactome and phenome

摘要：

BackgroundUnderstanding the complexity in genotypephenotype relationship is of vital importance for revealing the genetic basis of complex diseases. Recent studies on the basis of human interactome and phenome not only uncovers prevalent and intricate phenotypic overlap and genetic overlap between human diseases,but also reveals a modular organization of the genetic landscape of human diseases 1,thereby providing new opportunities to reduce the complexity in dissecting the genotypephenotype association and to facilitate the discovery of disease genes.

作者: Xuebing Wu Qifang Liu Rui Jiang

作者单位: MOE Key Laboratory of Bioinformatics, Bioinformatics Division, TNLIST / Department of Automation, Tsinghua University, Beijing 100084,China

会议类型: 国际会议

会议名称: The 7th Asia-Pacific Bioinformatics Conference(第七届亚太生物信息学大会)

会议地点: 北京

会议语种:英文

页码: 890

在线出版日期: 2009-01-01（万方平台首次上网日期，不代表论文的发表时间）