Integrative Online Tool for Simulation of Steady-state and Dynamic Cellular Networks
(0) IntroductionIt is increasingly accepted that steady-state and dynamic modelling and simulation of biological systems are promising to discover a knowledge map for elucidating the functions and characteristics of living systems in detail. Given the biochemical reaction network, kinetic and regulatory information can be incorporated into a model comprising continuous differential equations of linear programming problems. The model aims to completely describe the system and predict its behavior under any perturbations. Thus, it is highly desirable to establish an effective method and develop software tools for such kinetic modelling and concomitant simulation. To this end, various softwares and computational environments have been developed as listed in the systems biology community (http://sbml.org/); each tool has its own capability and strength in a wide range of feature combinations, e.g.,user interface, mathematical framework, and database functionality 1. Here, we report the development of WebCell, an integrated web-based environment which facilitates investigation of dynamic behaviors of cellular systems as and provides a collected model library as a pedagogic tool.
Hongseok Yun Choamun Yun Sang Yup Lee Sunwon Park
Department of Chemical and Biomolecular Engineering (BK21 Program), Process Systems Laboratory, KAIS Department of Chemical and Biomolecular Engineering (BK21 Program), Process Systems Laboratory, KAIS Metabolic and Biomolecular Engineering National Research Laboratory, Center for Systems and Syntheti
国际会议
The 7th Asia-Pacific Bioinformatics Conference(第七届亚太生物信息学大会)
北京
英文
899
2009-01-01（万方平台首次上网日期，不代表论文的发表时间）