Computational analysis of disease-related mutation effects on transcription factor binding

摘要：

BackgroundDetailed knowledge of the mechanisms of transcriptional regulation is very important in understanding the gene expression in its entirety. Transcription is regulated, among other things, by transcription factors that bind to DNA and can enhance or repress the transcription process. If a transcription factor fails to bind to DNA or binds to wrong DNA region,that can cause severe effects to gene expression, to the cell and even to the individual. The problems in transcription factor binding can be caused by wrong environmental conditions or the change in DNA structure which often occurs when parts of the DNA strands are mutated. An increasing number of the identified disease-related mutations occur in gene regulatory sequences. Mutations can disrupt the transcription factor binding site or create a new one (see Figure 1).

作者: Kirsti Laurila Harri L(a)hdesm(a)ki

作者单位: Department of Signal Processing, Tampere University of Technology, P.O.Box 527, FI-33101 Tampere, Finland

会议类型: 国际会议

会议名称: The 7th Asia-Pacific Bioinformatics Conference(第七届亚太生物信息学大会)

会议地点: 北京

会议语种:英文

页码: 907

在线出版日期: 2009-01-01（万方平台首次上网日期，不代表论文的发表时间）