An approach to the recovery of associations between protein domains and complez diseases
BackgroundThe application of gene-mapping techniques in modern human and medical genetics has been revolutionizing biomedical studies in searching for nonsynonymous single nucleotide polymorphisms(nsSNPs) underlying complex diseases and locating genes responsible for these diseases. Typically, a protein is composed of several structural domains, each of which is closely related to a specific function of the protein. It is therefore reasonable to assume that harmful nsSNPs alter structures of protein domains,affect functions of proteins, and finally cause disorders. With this understanding, we explore the possibility of recovering associations between protein domains and complex diseases with the use of domaindomain interaction network.
Wenhui Wang Wangshu Zhang Rui Jiang Yihui Luan
School of Mathematics and System Sciences, Shandong University, Jinan 250100, China Ministry of Education Key Laboratory of Bioinformatics, Bioinformatics Division, Department of Autom Ministry of Education Key Laboratory of Bioinformatics, Bioinformatics Division, Department of Autom School of Mathematics and System Sciences, Shandong University, Jinan 250100, China FIT 1-107, Tsing
国际会议
The 7th Asia-Pacific Bioinformatics Conference(第七届亚太生物信息学大会)
北京
英文
908
2009-01-01（万方平台首次上网日期，不代表论文的发表时间）