Chiral Transformation of Cyanine Dye Aggregates Induced by Small Peptides

摘要：

Three small peptides (K4, K5. And K6) with different length were designed to induce the transformation of the assembled state and die chirality of cyanine dye supramolecule. The absorption and circular dichroism (CD) results indicated that, the peptides tend to induce cyanine dye to H-aggregation, competed with Na+in PBS, which would induce dye to J-aggregation. Meanwhile, all three peptides could influence the chirality of both J-aggregates induced by Na+and H-aggregates, among which K6 could induce chiral reversion of J-aggregates. Furthermore, molecular modeling and energy calculation results have shown that the peptides with different chain length have different conformations. This might be the reason for cyanine dye to form the different chiral assembly induced by these oligo-peptide templates.

作者: Qianfan Yang Junfeng Xiang Qian Li Wenpeng Yan Qiuju Zhou Yalin Tang Guangzhi Xuf

作者单位: Beijing National Laboratory for Molecular Sciences (BNLMS), Center for Molecular Sciences, State Key Beijing National Laboratory for Molecular Sciences (BNLMS), Center for Molecular Sciences, State Key Beijing National Laboratory for Molecular Sciences (BNLMS), Center for Molecular Sciences, State Key Beijing National Laboratory for Molecular Sciences (BNLMS), Center for Molecular Sciences, State Key Beijing National Laboratory for Molecular Sciences (BNLMS), Center for Moleculr Sciences, State Key

会议类型: 国际会议

会议名称: 第四届国际分子模拟与信息技术应用学术会议(The 4th International Conference of Molecular Simulations and Applied Informatics Technologies)

会议地点: 广州

会议语种:英文

页码: 111-115

在线出版日期: 2008-11-01（万方平台首次上网日期，不代表论文的发表时间）