A comparative molecular dynamics study on thermostability of human and chicken prion proteins

摘要：

To compare the thermostabilities of human and chicken normal cellular prion proteins (HuPrPC and CkPrPC), molecular dynamics (MD) simulations were performed for both proteins at an ensemble level (10 parallel simulations at 400 K. and 5 parallel simulations at 300 K as a control). It is found that the thermostability of HuPrPC is comparable with that of CkPrPc, which implicates that the non-occurrence of prion diseases in non-mammals cannot be completely attributed to the thermodynamic properties of non-mammalian PrPC.

关键词： Prion protein Molecular dynamics simulation Salt bridge Unfolding Ensemble

作者: Hong-Fang Ji Hong-Yu Zhang

作者单位: Shandong Provincial Research Center for Bioinformalic Engineering and Technique, Center for Advanced Study, Shandong University of Technology.Zibo 255049.PR China

会议类型: 国际会议

会议名称: 第四届国际分子模拟与信息技术应用学术会议(The 4th International Conference of Molecular Simulations and Applied Informatics Technologies)

会议地点: 广州

会议语种:英文

页码: 554-558

在线出版日期: 2008-11-01（万方平台首次上网日期，不代表论文的发表时间）