Finite Element Simulation of Cell-substrate Debonding During Cyclic Stretch
Cardiac myocyte, because of its importance to human body, is always the focus of attention, not only the biologist but also the researchers of mechanics. In this paper, the strain acting on myocardial cells in vivo was simulated by exerting stretch loadings on myocardial cells cultured on silica substrate at different frequencies and in different duration, using a custom-made substrate stretch device. The effects of s tretch on the spreading shape and the ratio of the long axis to the short axis of cardiac myocytes wer e studied through morphocytology statistics. The results showed that the influences of substrate stretch on the morphology of cardiac myocytes varied with the stretch actuation duration. In conclusion, that a proper cyclic strain is stimulative to the adhesion and spreading of myocardial cells. Meanwhile, the development of an adhesive cell model with a nonlinear viscoelastic constitutive relationship is on going, to simulate the mechanical behavior of single cardiac myocyte in vitro under cyclic mechanical stimulation.
Cardiac myocyte mechanical ezcitation mechanical behavior numerical simulation
J Qiu T Tang M Zhang Z Zhuang
School of Aerospace, Tsinghua University, Beijing 100084, PR China
国际会议
北京
英文
1-5
2008-10-23（万方平台首次上网日期，不代表论文的发表时间）