A CMOS Active-Pizel Sensor Based DNA Micro-Array with Nano-Metallic Particles Detection Protocol
A DNA Micro-Array based on integrated CMOS Active Pixel Sensor utilizing the opacity of self-assembled nano-metallic particles is demonstrated. Due to the complementary nature of DNA hybridization process,the DNAfragments attached to the nano-pardcle precipitate them only at locations where complementary DNA strands exist. The opacity of the chip surface change due to accumulation of nano-metallic particles can be used to detect the existence of some targeted DNA fragments. Ordinary light sources can be used in this approach rather than special UV light sources in the most popular fluorescence based detection method. The chip has been fabricated with a 0.5μ m CMOS process and contains on-chip timing control,dynamic range enhancement by pulse-width modulation and correlated double sampling. The system can detect DNA sample with extremety low concentration down to 10pM under.
Mansun Chan
Department of Electronic and Computer Engineering Hong Kong University of Science & Technology Clear Water Bay,Kowloon,Hong Kong,China
国际会议
9th International Conference on Solid-State and Integrated-Circuit Technology(第9届固态和集成电路国际会议)
北京
英文
2545-2548
2008-10-20（万方平台首次上网日期，不代表论文的发表时间）