Synthesis and Solubilities Analysis of 3,28-Di-O-glutary-betulin
Introduction Betulin, also known as betulinol, is an abundant naturally occurring trierpene and it is found predominantly in bushes and trees forming the principal extractive(up to 30% of dry weight) of the bark of birch trees.Although betulin can also be isolated from other sources in small amounts, the extractive isolation of betulin on an industrial scale from birch bark waste could be a large and feasible source of raw material. White birches are widespread in the northern latitudes of the world, and currently there is no economically signigicant use for this easily isolable compound. The healing properties of birch bark and birch bark extracts have been known for a long time in folk medicine. Birch bark oil has been used for skin diseases, such as eczema and psoriasis. Betulin can be used as such or after chemical modification as a starting compound for other useful materials and compounds, which possess various interesting pharmacological properties. Betulin has several disadvantages. One of the major problem is its poor water solubility. To increase its water solubility and bioactivity, we need syntheses of water soluble betulin derivatives. These analogues have polar substituents coupled to betulin either at C3-or at C28-hydroxyl group. The solubilising moieties can be carboxylic acids, phosphates, sulphonates or amines. In most cases these moieties are coupled to betulin via an ester linkage.
LV Kun TIAN Shui-qing FANG Gui-zhen
Key Laboratory of Bio-based Material Science and Technology, Northeast Forestry University, Ministry of Education, Harbin 150040,China
国际会议
International Symposium on Wood Science and Technology(IAWPS 2008)(国际木材产品学会联合会2008学术研讨会)
哈尔滨
英文
295-296
2008-09-27（万方平台首次上网日期，不代表论文的发表时间）