Evaluation of GBE50 against Myocardial Ischemia-Reperfusion Injury with Myocardial Mechanics and Hemodynamic Information

摘要：

Objective: To observe the protective effects of Ginkgo biloba extract(GBE50) on the myocardial ischemia-reperfusion injury(Irl) of rats, and to investigate the evaluating functions of myocardial mechanics and hemodynamic information. Methods:65 SD rats were randomly allocated into 6 groups:model group, GBE50 low/middle/ high dosage group,Danshen group, and Diltiazem group. The perfusion was stopped for 30 rain after the heart was perfused in vitro for 15 rain, and then it was reperfused for 40 rain.The pressure in the left ventricle was recorded to observe the effects of drugs on myocardial mechanics and hemodynamics. Results: middle dosage of GBESO,Danshen, and Diltiazen could improve the heart functions after IRI, DP and ±dp/dtmax were higher than those in the model group, and t-dp/dtmax and LVDP were lower than those in the model group.Conclusion: GBESO could prevent the decrease of heart function after 1R1 to protect the heart function.And evaluation with myocardial mechanics and hemodynamic information is stable and credible.

作者: Yimin Bao Jiatuo Xu Zhixiong Zhang

作者单位: Shanghai University of Traditional Chinese Medicine,Shanghai,201203,China

会议类型: 国际会议

会议名称: 2008 IEEE International Symposium on IT in Medicine and Education(2008信息技术在医学和教育中的应用国际研讨会)(ITME 2008)

会议地点: 厦门

会议语种:英文

页码: 543-547

在线出版日期: 2008-12-12（万方平台首次上网日期，不代表论文的发表时间）