EFFECT OF ELECTRET ON TRANSDERMAL PERM EATION OF MELOXICAM FROM A PATCH FORMULATION

摘要：

In this study,the effect of electret and 10％ethyl oleate on meloxicam skin permeation was studied by improved Franz diffusion cell，UV measurement and HPLC analysis.The results indicated that electret had better enhancing effect on the skin permeation of meloxicam than that of 10％ethyl oleate.Moreover,electret and 10％ethyl oleate had an incorporative effect that could lead to a stable transdermal flux of meloxicam of 6.531μg/cm2·h and 79％of the drug permeating through the skin after apply ing the patch on skin for 6h.Conclusion：electret meloxicam patch had better transdermal enhancing effect.

关键词： electret meloxicam transdermal delivery patch

作者: Jiang Jian Kong Yuxiu Cheng Liang Hou Xuemei Liang Yuanyuan Wang Dong Xiao Yongheng Cui Lili

作者单位: Department of Physics and Mathematics,Faculty of Basic Medical Sciences,Second Military Medical Univ Department of Inorganic Chemistry,School of Pharmacy,Second Military Medical University,Shanghai,200

会议类型: 国际会议

会议名称: The 6th International Conference on Applied Electrostatics(第六届国际静电应用会议)

会议地点: 上海

会议语种:英文

页码: 200-202

在线出版日期: 2008-11-03（万方平台首次上网日期，不代表论文的发表时间）