THE SIZE EFFECT OF RECEPTOR-MEDIATED ENDOCYTOSIS

摘要：

Receptor-mediated endocytosis is an important approach that the viruses enterthe host cells.A simple energy principle model is developed and the Hertz contacttheory is used to calculate the elastic deformation energy of the cytoskeleton duringendocytosis.Some results,such as the optimal virus radius,the criticalligand-receptor binding energy density and the upper and low limits of the virusradius,can be obtained according to this model.The research about the size effecton receptor-mediated endocytosis can help us to design the more logical size ofdrug carrier.

关键词： Size effect receptor-mediated endocytosis optimal radius drug carrier

作者: S.J.Wang X.Li

作者单位: College of Engineering & Technology,Southwest University,Chongqing 400716,PR China College of Engineering & Technology,Southwest University,Chongqing400716,PR China

会议类型: 国际会议

会议名称: 第二届国际非均质材料力学会议(The Second International Conference on Heterogeneous Material Mechanics)

会议地点: 安徽黄山

会议语种:英文

页码: 593-597

在线出版日期: 2008-06-03（万方平台首次上网日期，不代表论文的发表时间）