Corpus Callosum Morphometry in High Functioning Autism
OBJECTIVE: Mapping corpus callosum deficits in high functioning autism(HFA).METHOD: Seventeen children with HFA and sixteen typically developing(TD)children underwent a 3D TI-weighted scan.Global and regional corpus cailosum volume and density measures were compared between groups.RESULTS: Reduced density of the anterior third region in HFA compared with TD children was found.This difference remained when covaried for IQ or cerebral volume.While when covaried for age,the significant effect of anterior third disappeared.CC volumes were positively correlated with IQ in the posterior midbody and isthmus in TD group.CC volumes were negatively correlated with severity of symptoms in HFA group.CONCLUSIONS: These results suggest that anterior third region was most affected in HFA children and related to severity of symptoms,which is consistent with the hypothesis of cortical underconnectivity in autism.
HONG Shan-shan KE Xiao-yan TANG Tianyu HUANG Haiqing ZOU Bing LI Huiguo HANG Yueyue LU Zuhong
Key Laboratory of Child Development and Learning Science(Southeast University),Ministry of Education Key Laboratory of Child Development and Learning Science(Southeast University),Ministry of Education Child Mental Health Research Center of Nanjing Brain Hospital affiliated of Nanjing Medical Universi
国际会议
2008亚太心智、脑和教育学术会议(Asia-Pacific Conference on Mind Brain and Education 2008)
南京
英文
404-407
2008-10-25（万方平台首次上网日期，不代表论文的发表时间）