Optimal Molding Parameter Design of PLA Micro Lancet Needles using Taguchi Method
Microneedles can be used for biomedical applications such as skin prick,blood collection,and drug delivery,etc.Many of the microneedles were fabricated by traditional machining.In this study,a micro lancet needle for blood test application was fabricated using micro injection molding technique,biodegradable polylactic acid (PLA) was used as molding material.The dimension of the microneedle is 623 μm in length,203 μm in width,and 106 μm in thickness.The mold insert for molding this microneedle was fabricated using LIGA-like techniques.ANSYS CAE software was employed to determine the microneedles dimensions,and the strength of microneedle was designed to withstand a pressure higher than 3.5 MPa which is necessary for breaking through human skin.Micromolding of the design microneedle was carried out using Battenfeld Microsystem 50 microinjection molding machine.In order to achieve optimal microneedle quality,Taguchi method was utilized in the experiment.The injection molding parameters including melt temperature,mold temperature,injection speed,and holding speed have been selected as control parameters in the experiment.Experimental results showed that melt temperature and mold temperature have the most significant effects on the strength of the PLA microneedles,and this study also demonstrates that LIGA-like and micromolding techniques can been applied for mass replication of microneedles.
LIGA-like Microneedle Taguchi method Micro Injection Molding
Min-Wen Wang Gong-Loung Fu Jia-Haur Jeng
Department of Mechanical Engineering,National Kaohsiung University of AppliedSciences Technology Department of Mechanical Engineering,Minghsin University of Science andTechnology Department of Mechanical Engineering,National Kaohsiung University of Applied Sciences Technology
国际会议
北京
英文
2008-10-12（万方平台首次上网日期，不代表论文的发表时间）