Effect of EMP on Superoxide Dismutase and Malondialdehyde in K562 cells

摘要：

AIM To observe effect of EMP on the kinetic equilibrium of produce and elimination of free radicals.METHODS Human erythroleukemia K562 cells were exposed or shamly exposed to EMP before the activity of SOD and the contents of MDA were measured using NBT and TBA methods respectively.RESULTS The activity of SOD decreased 12h after 200kV·m-1 EMP exposure,the contents of MDA increased 24h after 200kV·m-1EMP exposure.The contents of MDA increased and the activity of SOD decreased at 12h and 24h after 400kV·m-1EMP exposure.CONCLUSION Excessive free radicals produced from impact of EMP on the kinetic equilibrium of produce and elimination of free radicals maybe a way through which EMP exposure inducing cell damage.

关键词： electromagnetic pulse (EMP) Free radical Superoxide Dismutase (SOD) Malondialdehyde (MDA) K562

作者: Xue-Jun Xie Gui-Ying Zeng Yao Guo Guo-Zheng Guo Li-Hua Zeng Dong-Qing Ren

作者单位: Department of Radiation Medicine,Faculty of Preventive Medicine,Fourth Military Medical University,Xian 710032,China

会议类型: 国际会议

会议名称: 7th Asian-Pacific Conference on Medical and Biological Engineering(第七届亚太地区生物工程学术会议)

会议地点: 北京

会议语种:英文

在线出版日期: 2008-04-22（万方平台首次上网日期，不代表论文的发表时间）