Synthesis, Characterization and Cell-uptake of Porphyrin-capped Gold Nanoparticle

摘要：

In order to improve the cell uptake effect of porphyrins and their derivatives,gold nanoparticle was chosen as carrier.We report our preliminary result on synthesis and characterization of thiol tailored porphyrin and porphyrin capped gold nanoparticle,their interaction with cell by TEM,UV-Visible spectra,fluorescent spectra and confocal microscopy.Our results show that porphyrins modified gold nanoparticles have low cytotoxicity and acceptable fluorescence emission,and reliable cell uptake ability.Gold nanoparticle is an ideal carrier to delivery the porphyrin molecule into cell which make porphyrin modified gold nanoparticles as a potential agent in PDT and molecular image.

关键词： Iporphyrin gold nanoparticle cell uptake photosensitizers fluorescence probe

作者: Lü Feng Liu Tianjun Wu Li

作者单位: Institute of Biomedical Engineering,Chinese Academy of Medical Sciences & Peking Union Medical College,The Tianjin Key Laboratory of Biomaterial Research,Tianjin 300192,PR China

会议类型: 国际会议

会议名称: 7th Asian-Pacific Conference on Medical and Biological Engineering(第七届亚太地区生物工程学术会议)

会议地点: 北京

会议语种:英文

在线出版日期: 2008-04-22（万方平台首次上网日期，不代表论文的发表时间）