Fabrication of porous β-TCP scaffolds by combination of rapid prototyping and freeze drying technology

摘要：

The scaffold with exact shape and polygradient inner structure was necessary for bone tissue engineering scaffolds to facilitate cells infiltration and proliferation.A novel method of designing and preparing bone tissue engineering scaffolds with polygradient controllable structure of both macro and micro pores was proposed in this paper.By integrating rapid prototyping and freeze drying technology,the macro and micro pores were formed respectively.The size,shape and quantity of micropores were controlled by slurry concentration.The sintered β-TCP porous scaffolds were with connective macropores of approximately 400μm and micropores of 50～300μm.The chemical composition,porosity and mechanical properties of scaffolds were measured and analyzed.The detected results indicated that the β-TCP scaffolds could fulfill the requirements of tissue engineering.

关键词： scaffolds Tissue engineering FDM Freeze drying β-TCP

作者: Liulan Lin Shaohua Ju Lian Cen Huicun Zhang Qingxi Hu

作者单位: Rapid Manufacturing Engineering Center,Shanghai University,China Shanghai Tissue Engineering Research and Development Center,China

会议类型: 国际会议

会议名称: 7th Asian-Pacific Conference on Medical and Biological Engineering(第七届亚太地区生物工程学术会议)

会议地点: 北京

会议语种:英文

在线出版日期: 2008-04-22（万方平台首次上网日期，不代表论文的发表时间）