Effect of microstructure on the mechanical properties and biology performance of bone tissue scaffolds using selective laser sintering
Porous β-tricalcium phosphate (β-TCP) ceramic scaffolds with axially oriented macropore and random micropore were produced by selective laser sintering (SLS) process.Microstructure parameters including pore size,pore size distribution and interconnectivity were quantified by microcomputed tomography.Compressive mechanical properties were tested.The porosity of sintered scaffolds was over 60％.The range of average compressive modulus and ultimate strength was 24.38～30.64MPa and 1.64～2.35MPa,respectively.Dog bone marrow stromal cells (BMSCs) were seeded in the prepared scaffolds.Cell proliferation and osteogenic differentiation on the scaffolds were evaluated with the alkaline phosphatase (ALP) activity and osteocalcin (OCN) content.
Bone tissue engineering β- tricalcium phosphate Selective laser sintering Porous scaffold
Liulan Lin Jiafeng Zhang Li Zhao Aili Tong Jian Sun Qingxi Hu
Rapid Manufacturing Engineering Center,Shanghai University,Shanghai 200444,China Shanghai Tissue Engineering Research and Development Center,Shanghai,200233,China
国际会议
7th Asian-Pacific Conference on Medical and Biological Engineering(第七届亚太地区生物工程学术会议)
北京
英文
2008-04-22（万方平台首次上网日期，不代表论文的发表时间）