Drug controlled release of novel alginate/poly-L-arginine microcapsules

摘要：

A novel alginate/poly-L-arginine microcapsules were prepared by emulsification using bovine hemoglobin (Hb) as the model drug,and the impact of the release properties such as the molecular weight of poly-L-arginine,the concentration of sodium alginate and calcium chloride were investigated.The microcapsules made from middle molecular weight of poly-L-arginine (PLA) had obviously sustained release profile.The impact of sodium alginate concentration on the release properties was not obviously,the release rate of microcapsules made with 12％ (w/v) CaCl2 were slightly faster,but the accumulative release rate were nearly the same.The microcapsules had so obviously sustained drug release that this novel microcapsules may be used as a promising drug delivery system for hydrophilic proteins and peptides.

关键词： microcapsule poly-L-arginine alginate emulsification controlled release

作者: Wenguo Wu Wei Liu Shibin Wang Yuangang Liu

作者单位: college of Materials Science & Engineering,Huaqiao University,Quanzhou,China college of Materials Science & Engineering,Huaqiao University,Quanzhou,China;Research Institute of P

会议类型: 国际会议

会议名称: 7th Asian-Pacific Conference on Medical and Biological Engineering(第七届亚太地区生物工程学术会议)

会议地点: 北京

会议语种:英文

在线出版日期: 2008-04-22（万方平台首次上网日期，不代表论文的发表时间）