Preparation and physicochemical characteristics of self-assembled nanoparticles of cholesterol succinate modified pullulan conjugates

摘要：

A series of cholesterol-modified pullulan (CHSP) conjugates with different degrees of substitution (DS) of cholesterol moiety were synthesized by the succinyl linkages and characterized by Fourier transform infrared (FTIR) and proton nuclear magnetic resonance (1H NMR).CHSP conjugates were amphiphilic in nature and their self-aggregation behavior in aqueous media was evaluated by the fluorescence probe technique.CHSP self-aggregated nanoparticles were prepared by dialyzed in water and analyzed by dynamic laser light-scattering (DLLS),zeta potential and transmission electron microscopy (TEM) technologies.

关键词： cholesterol succinate modified pullulan Selfassembled nanoparticle

作者: Wen-Zhi Yang Qi-Qing Zhang Hong-Li Chen Xue-Ming Li Qian Jiang Min-Mao Chen Fu-Ping Gao Hui-Zhu Zhang

作者单位: Institute of Biomedical Engineering,Chinese Academy of Medical Science & Peking Union Medical Colleg Institute of Biomedical Engineering,Chinese Academy of Medical Science & Peking Union Medical Colleg

会议类型: 国际会议

会议名称: 7th Asian-Pacific Conference on Medical and Biological Engineering(第七届亚太地区生物工程学术会议)

会议地点: 北京

会议语种:英文

在线出版日期: 2008-04-22（万方平台首次上网日期，不代表论文的发表时间）