Baroreflex sensitivity with the undulation pump artificial heart
The aim of this study was to examine the baroreflex sensitivity in a goat with undulation pump ventricular assist device (UPVAD).The pump was implanted into the thoracic cavity of the goat by left thoracotomy,and the inflow and outflow cannulae were sutured to the apex of left ventricle and to the descending aorta,respectively.Its driving cable was wired percutaneously to the controller outside;Electrocardiogram and hemodynamic waveforms were recorded at the sampling frequency of lkHz.BRS was determined in the awake condition by the slope of linear regression of R-R interval against mean arterial pressure changes,which had been induced by the administration of methoxamine hydrochloride,with continuous driving mode of UPVAD as well as without assistance.BRS values during the UPVAD support and without assistance were calculated to be 1.60±0.30 and 0.98 4±0.22 msec/mmHg (n=5,p＜0.05),respectively.BRS were significantly improved during left ventricle assistance.Therefore it was suggested that the UPVAD support might decrease sympathetic nerve activity and parasympathetic nerve activity was increased.The UPVAD might improve both mierocireulation and organ function.
baroreflex sensitivity undulation pump ventricular assist device R-R interval
H.J.Liu Y.Shiraishi X.M.Zhang Y.Saijo H.J.Song A.Baba T.Yambe Y.Abe K.Imachi
Institute of Development and Aging Cancer,Tohoku University,Sendal,Japan School of Public Health,Jilin University,Changchun,China Dept.of Mechanical Engineering,KAIST,Daejon,Republic Of Korea Tohoku University Biomedical Engineering Research Organization,Sendal,Japan Dept.of Biomedical Engineering,Graduate School of Medicine,the University of Tokyo,Tokyo,Japan
国际会议
哈尔滨
英文
306-309
2008-01-13（万方平台首次上网日期，不代表论文的发表时间）