Effect of Electroacupuncture on Cerebral Ischemia:Earlier Application,Better Protection
Objective: To observe if an earlier application of electroacupuncture (EA) leads to a better protection against cerebral ischemia.Methods: Adult rats were subjected to right middle cerebral artery occlusion (MCAO) for 1 h,followed by 24-hour reperfusion.EA was delivered to Baihui (GV 20) and Shuigou (GV 26) for 30 min before MCAO (EA before MCAO,EBM),or starting at 5 minutes after the onset of MCAO (EA during MCAO,EDM) and after 5 rain of reperfusion (EA after MCAO,EAM).Results: The results showed that MCAO decreased the blood flow by 85％,resulting tissue infarction (33.3％±5.4％ of the whole brain),neurological deficit (scales=5-7) and animal death (16％).EBM slightly reduced the brain infarction and the neurological deficit with no animal death.EDM led to the best protective effect with the infarct volume being reduced to only 3.9％±1.2％ (P<0.01 vs.MCAO alone or EBM) and neurological deficit scale,to 0.5 degree (P<0.01).In EAM group,the brain infarction was slightly reduced (24.5％±6.4％,P<0.05 vs.MCAO alone) and neurological deficit scale was decreased from 6 to 4 degrees (P<0.05) with a death rate of 8.3％.In the MCAO brains,the blood flow was constantly low during MCAO and in the initial period of reperfusion.In the EBM group,the blood flow rapidly increased after MCAO though EA stimulation did not influence the blood flow before and during MCAO.EDM significantly increased blood flow during MCAO and induced a rapid recovery during reperfusion,while EAM improved the blood flow recovery during reperfusion.Conclusion: Our data suggest that an earlier application of EA during MCAO leads to better protection from cerebral ischemia,partially due to the regulation of the blood flow in the ischemic brain.
ZHOU Fei GUO Jing-chun CHENG Jie-shi WU Gen-cheng XIA Ying
Shanghai Research Center of Acupuncture and Meridian,Shanghai 201203,P.R.China;Fudan University Shan Fudan University Shanghai Medical College,Shanghai 200433,P.R.China;Shanghai Research Center of Acup Shanghai Research Center of Acupuncture and Meridian,Shanghai 201203,P.R.China;Yale University Schoo
国际会议
The 3rd Workshop on Scientific Approaches to Chinese Medicine(第三届中医科学研究方法研讨会)
安徽黄山
英文
311
2008-10-25（万方平台首次上网日期，不代表论文的发表时间）