European and Far East Mistletoes:Potential in Adjuvant Cancer Therapy
Semiparasitic plants,mistletoes,distributed in Europe and East-Asia mainly,China,Korea and Japan have long been recognised as therapeutic herbs.Since the 1920s,extracts from European mistletoe(Viscum album L) have been popular in Europe as an unconventional cancer treatment.These extracts have been used in adjuvant cancer therapy because their immunostimulatory,cytostatic/cytotoxic and DNA stabilising activities.The main biological activities are addressed to sugar binding proteins,the Mistletoe Lectins,and to micro proteins named viscotoxins.The mistletoe lectins are members of the family of toxic lectins and recognize sugars and glycoconjugates containing galactose and/or N-acetyl-galactosaminc groups.In vitro and in vivo assays confirm that the mistletoe lectins,isolated from the plant and compared with recombinant forms,play an important role as biologically active principles in mistletoe extracts.Limited experimental evidence indicates that other components like glycosides,polysaccharides,amines etc,may also have anticancer activity.Under discussion in Europe is the principal question of using holo plant extracts or single component lectin preparations: wild type lectins or recombinant ones in cancer therapy.Finally problems of preparation,characterization and standardization of commercial mistletoe preparations and evaluation of biological activities are discussed.
Neoplasms Second Primary Lectins Colored Mistletoe Herb
Uwe PFULLER Udo SCHUMACHER
University Hamburg,Universitatsklinikum Hamburg-Eppendorf(UKE).Institute of Anatomy Ⅱ.Experimental Morphology,Hamburg 20246,Germany
国际会议
The 3rd Workshop on Scientific Approaches to Chinese Medicine(第三届中医科学研究方法研讨会)
安徽黄山
英文
284-285
2008-10-25（万方平台首次上网日期，不代表论文的发表时间）