Minimal Model of Calcium Dynamics Induced by Laser Irradiation in Mast Cells
Recent experiments show that calcium signaling and degranulation dynamics induced by low power laser irradiation in mast cells must rely on extracellular Ca2+ influx.An analytical cxpression of Ca2+ flux through TRPV4 cation channel in response to interaction of laser photon energy and extracellular Ca2+ is deduced,and a minimal model characterizing dynamics of calcium signaling and degranulation activated by laser irradiation in mast cells is established.The model indicates that the characteristics of calcium signaling and degranulation dynamics are determined by interaction between laser photon energy and Ca2+ influx.Extracellular Ca2+ concentration is so high that only smaller photon energy can activate mast cells,thus avoiding the possible injury caused by laser irradiation with shorter wavelengths.The model predicts that there exists a narrow parameter domain of photon energy and extracellular Ca2+ concentration of which results in cytosolic Ca2+ limit cycle oscillations,and shows that PKC activity is in direct proportion to the frequency of Ca2+ oscillations.With the model it is found that sustained and stable maximum plateau of cytosolic Ca2+ concentration can get optimal degranulation rate.Furthermore,the idea of introducing the realistic physical energy into model is applicable to modeling other physical signal transduction systems.
SHI Xiao-min
Institute of Systems Science,Shanghai University,Shanghai 200444,P.R.China
国际会议
The 3rd Workshop on Scientific Approaches to Chinese Medicine(第三届中医科学研究方法研讨会)
安徽黄山
英文
283
2008-10-25（万方平台首次上网日期，不代表论文的发表时间）