Effect of Electroacupuncture on Experimental Epilepsy:Roles of Different Acupoints and Stimulation Parameters
Objective: The strategies against epilepsy are currently very limited.The author performed this work to determine the effect of electroacupuncture(EA) on epileptic seizures and define the optimal EA conditions(acupoints and stimulation parameters).Methods:Experimental epilepsy was induced by injecting kainic acid into the lateral cerebral ventricle of adult male SD rats.EA with a current of 1 mA/100 Hz or 1 mA/10 Hz was applied to the model starting at 0.5 h after the injection for 30 min.Four pairs of acupoints were tested,including Renzhong(GV 26) + Dazhui(GV 14),Jinsuo(GV 8)+ Yaoqi(Ex-B 9),Neiguan (PC 6) +Quchi (LI 11) and Fenglong (ST 40) + Yongquan (KI 1). Results: Behavioral scores showed that (1) either high (100 Hz) or low (10 Hz) frequency EA at different acupoints attenuated epileptic seizures (P<0.05 or 0.01 vs.the control),except EA at Neiguan (PC 6) + Quchi (LI 11)with 1 mA/10 Hz current; (2) EA with low frequency stimulation (10 Hz) induced a better effect at Fenglong (ST 40) + Yongquan (KI 1) than other acupoints (P<0.05 or 0.01); (3) there was no significant difference in EA effects induced by various acupoints when exposed to high frequency EA (100 Hz); and (4) high frequency EA (100 Hz)elicited a better effect than low frequency EA (10 Hz) in all groups (P<0.05 or 0.01) except for that of Jinsuo (GV 8) + Yaoqi (Ex-B 9).EEG showed the similar tendency,i.e.,EA generally reduced the amplitude and frequency of epileptic discharges.Conclusion: Electroacupuncture attenuates epileptic seizures,which is relatively specific to EA parameters and acupoints.
Epilepsy Electroacupuncture Acupuncture Points
KANG Xue-zhi XIA Ying
Shanghai Research Center of Acupuncture and Meridian,Shanghai 201203,P.R.China Shanghai Research Center of Acupuncture and Meridian,Shanghai 201203,P.R.China;Yale University Schoo
国际会议
The 3rd Workshop on Scientific Approaches to Chinese Medicine(第三届中医科学研究方法研讨会)
安徽黄山
英文
279-280
2008-10-25（万方平台首次上网日期，不代表论文的发表时间）