Different Effects and Peripheral Mechanism between Manual-acupuncture and Electroacupuncture on Mast Cell Function and Acupuncture Analgesia by Nerve Block in Acupionts
Objective:To observe the effects of nerve block on MA and EA analgesia and mast cells degranulation in adjuvant arthritis rats in order to analyze the difference between the underlying peripheral mechanism of MA and EA analgesia.Methods: Zusanli (ST 36) was chosen as the acupuncturing point on adjuvant arthritis rats.Eighty SD rats were randomized into 10 groups,including control,model,normai+Lido,EA,Lido+EA,DLido+ZEA,Xlido+ZEA,MA,Lido+MA,Dlido+ZMA groups,with 8 rats in each group.Paw Withdraw Latencies and mast cells degranulation ratios were recorded and computed.Results: Compared with model group,the pain threshold (PT) and mast cells degranulation ratios of EA and MA groups were obviously increased (P<0.05 or P<0.01 ).The analgesia effects of both MA and EA were obviously attenuated after nerve block by pretreated with Lidocaine hydrochloride at the acupuncturing point or at the acupiont of proximal end in the same neural stem while they were not by the same manipulations at the acupoint of distal end.Degranulation ratios of mast cells caused by MA or EA were not obviously affected by nerve block.Conclusion: The effective signal of nerve conduction of MA analgesia is generated alter the degranulation of mast cells in the process of acupoints activation or needle sense and it is the direct cause of generation of nerve signal.In the condition of EA,the acupoints activation is caused by the stimulation of electric signal on nerve reccptor while the degranulation of mast cells is concomitant or feedback effect.
Nerve Block Manual Acupuncture Electroacupuncture Acupuncture Analgesia Mast Cells Rats
HUANG Hong ZHAN Rui YU Xiao-jia ZHANG Di LI Wei-min DING Guang-hong
Department of Mechanics and Engineering Science,Fudan University,Shanghai 200433,P.R.China Shanghai Research Center of Acupuncture and Meridian,Shanghai 201203,P.R.China Department of Mechanics and Engineering Science,Fudan University,Shanghai 200433,P.R.China;Shanghai
国际会议
The 3rd Workshop on Scientific Approaches to Chinese Medicine(第三届中医科学研究方法研讨会)
安徽黄山
英文
273-275
2008-10-25（万方平台首次上网日期，不代表论文的发表时间）