Poly (L-lactic acid)/Chitosan Nano/Micro Fiber-Sheet Promotes Osteoblast Adhesion and Differentiation
Natural bone is actually an inorganic/organic composite mainly made up from nano/micro-structure of hydroxyapatite and collagen fibers.It is important to synthesize nano-composites of inorganic/organic with good biocompatibility,high bioactivity and great bonding property as potential material used for tissue engineering.The objective of this study was using natural materials to develop a three-dimensional (3D) porous tissue engineering scaffold for osteoblast engineering.In this study nano/micro fiber sheets with an average fiber diameter controllable from 0.8μm to 1.2μm were fabricated by electrospinning solutions containing poly (L-lactic acid) (PLLA) and chitosan (Cs).In this paper we explored the electrospinning conditions using poly (L-lactic acid) (HFIP solution) and chitosan (acetic acid solution).Further more;the physics-chemical properties of the samples were studied using degradation tests and water contact angle.The result suggest that PLLA/CS nano/micro fiber-sheet have higher hydrophilicity and better degradability than PLLA nano/micro fiber-sheet that can be a potential candidate for osteoblast engineering with enhanced biocompatibilities and degradability.
PLLA Chitosan Electrospinning Osteoblast
X Bao A Teromoto K Abe
Department of Functional Polymer Science,Faculty of Textile Science and Technology,Shinshu University,Ueda 386-8567,Japan
国际会议
杭州
英文
2008-10-15（万方平台首次上网日期，不代表论文的发表时间）