A Novel Route for Fabrication of Thermoresponsive Hollow Poly(N-isopropylacrylamide) Nanocapsules
Hollow polymeric nanocapsules have attracted great attentions in recent years due to their broad applications in drug delivery, controlled release, and microreactors.1,2 Recently, click chemistry provides a convenient way for the preparation of functional materials.3 Herein, we report the preparation of hollow poly(N-isopropylacryl-amide) (PNIPAM) nanocapsules via the combination of surface-initiated atom transfer radical polymerization (ATRP) and click cross-linking, followed by HF etching of SiO2 cores (Figure 1). Firstly, surface-initiated ATRP of NIPAM and 3-azidopropylacrylamide (AzPAM) was conducted in 2-propanol suing silica nanoparticles surface-dcrivatized with functional initiators. Poly(N-isopropylacrylamide-co-3-azidopropylacrylamide),P(NIPAM-co-AzPAM), brushes at the surface of silica cores were then cross-linked by 1,1,1-tris(4-(2-propynyloxy)phenyl)ethane via click reaction. The subsequent etching of silica cores of corona cross-linked hybrid silica nanoparticles by HF resulted in the formation of hollow PNIPAM nanocapsules. The whole process was evidenced by TEM (Figure 2). The obtained hollow PNIPAM nanocapsules exhibited reversible thermosensitive swelling/collapse transitions.
WU Tao LIU Shiyong
Key Laboratory of Soft Matter Chemistry,Department of Polymer Science and Engineering,Hefei National Laboratory for Physical Sciences at the Microscale,University of Science and Technology of China,Hefei,Ankui 230026,China
国际会议
5th East-Asian Polymer Conference(第5届东亚高分子学术研讨会)
上海
英文
253-254
2008-06-03（万方平台首次上网日期，不代表论文的发表时间）