Enzyme-Catalyzed Degradation of Biodegradable Polylactides

摘要：

Polylactide (PLA) has been receiving more and more interest for various biomedical and environmental applications due to its availability from renewable resources, good biocompatibility, degradability and mechanical properties.1 The hydrolytic degradation of large-size PLA polymers is characterized by internal autocatalysis of carboxyl end groups, which leads to faster internal degradation.1 Biodegradation of PLA also occurs in soil under natural outdoor conditions, indicating that PLA is an environmentally friendly material. The degradation of PLA in the presence of enzymes has been investigated by many groups. Proteinase K, a protease secreted by the fungus Tritirachium album Limber, was found to strongly accelerate PLA degradation.2 It was also observed that proteinase K preferentially degraded poly(L-lactide) as opposed to poly(D-lactide), amorphous zones asopposed to crystalline ones.3

作者: Yong He Zhenxian Zhao Jia Wei Suming Li

作者单位: Department of Materials Science,Fudan University,Shanghai 200433,China;Max Mousseron Institute on Bi Department of Materials Science,Fudan University,Shanghai 200433,China Department of Materials Science,Fudan University,Shanghai 200433,China;Max Mousseron Institute on Bi

会议类型: 国际会议

会议名称: 5th East-Asian Polymer Conference(第5届东亚高分子学术研讨会)

会议地点: 上海

会议语种:英文

页码: 154-155

在线出版日期: 2008-06-03（万方平台首次上网日期，不代表论文的发表时间）