Nano-Scaled Hollow Sphere Miceiles with Hydrophilic Channels and the Controlled Release of Ibuprofen
Polymeric vesicles or hollow spheres usually contain a comparatively independent space, and they were usually considered to be one of the best apparatus as drug containers, nano-reactors etc.1-3 In order to increase the permeability of hollow spheres or vesicles, hollow spheres with hydrophilic channel in the shell weresynthesized in this study. Poly(styrene)-block-poly(acrylic acid) (PS53-b-PAA69) hollow sphere micelles wereprepared through the conventional method4-6 except that some 1,2-dichloroethane was added into the block copolymer N,N-dimethylformamide (DMF) solution to enhance the core of the micelles7. Then hydrogenbonding constructed poly(acrylic acid)/poly(4-viynl pyridine) (PAA/P4VP) complex semi-permeable layer wasintroduced to both support the shrunk PNIPAM layer and connect with the PEG hydrophilic channel molecules.The resultant micelles contain an independent hollow space, a thin PS layer with lacunas, semi-permeablePAA/P4VP complex layer, and the shrunk PNIPAM layer with PEG channel. Small molecules drugs, just likeibuprofen, can only pass through the PNIPAM layer via the channel around PEG chains for that the PNIPAM shrunk layer is barrier for the diffusion of small molecules. Consequently, the release velocity can be controlledby verifying the thickness of the collapsed PNIPAM layer or the density of the channels.
Dean Xiong Yingli An Zhe Li Rujiang Ma Yang Liu Chenglin Wu Lu Zou Linqi Shi
Key Laboratory of Functional Polymer Materials,Ministry of Education,Institute of Polymer Chemistry,Nankai University,Tianjin 300071,P.R.China
国际会议
5th East-Asian Polymer Conference(第5届东亚高分子学术研讨会)
上海
英文
125-126
2008-06-03（万方平台首次上网日期，不代表论文的发表时间）