Monitoring the Average Molecular Weight and Molecular Weight Distribution during Polymer Degradation by PFG NMR

摘要：

Degradable polymers have found numerous applications in industry. Understanding their degradationmechanisms under various conditions is of special importance in order to improve their properties and to designnew structures of such polymers. In this study, the degradation of two biodegradable polymers, namelycross-linked polyethyleneimine (c-PEI) and γ-polyglutamic acid (γ-PGA) were monitored by real-time 1H-NMRspectroscopy and PFG NMR. 1H 2D COSY and HSQC NMR spectroscopy were also employed to elucidate thestructural changes during degradation. These same polymers have recently attracted specific attention due totheir potential use as gene-carriers.

作者: Min Peng Wei Liu Guang Yang Qun Chen Eddy W.Hansen

作者单位: physics Department & Shanghai Key Laboratory of Magnetic Resonance,East China Normal University,Shan University of Oslo,Department of Chemistry,P.O.Box 1033 Blindern,N-0315 Oslo,Norway

会议类型: 国际会议

会议名称: 5th East-Asian Polymer Conference(第5届东亚高分子学术研讨会)

会议地点: 上海

会议语种:英文

页码: 40-41

在线出版日期: 2008-06-03（万方平台首次上网日期，不代表论文的发表时间）