Photo-crosslinked Poly(ε-caprolactone fumarate) Networks for Peripheral Nerve Regeneration
Peripheral nerve injuries have been a challenging clinical problem.1 Synthetic nerve conduits have attractedgreat attention and numerous biocompatible polymers have been used to fabricate nerve conduits to bridge thegap between injured peripheral nerve stumps.1 Numerous crosslinkable polymeric systems have been developedin our laboratory for hard and soft tissue engineering applications.2,3 Among them, poly(caprolactone fumarate)(PCLF) shown below is a copolymer synthesized through polycondensation of PCL diol and fumarate chloride.2Here we present their photo-crosslinking characteristics as well as physical properties after crosslinking. Ascandidate materials for peripheral nerve regeneration, PCLFs have been fabricated into two-dimensional fiatdisks for investigating cell-material interactions using SPL201 cells, a Schwann cell precursor line, and three-dimensional nerve conduits for guiding axon growth in a rat sciatic nerve defect model.
Shanfeng Wang Michael J.Yaszemski Andrew M.Knight Anthony J.Windebank Lichun Lu
Department of Materials Science and Engineering,The University of Tennessee,Knoxville,Tennessee 3799 Departments of Orthopedic Surgery,Mayo Clinic College of Medicine,Rochester,Minnesota 55905,USA;Depa Departments of Neurology,Mayo Clinic College of Medicine,Rochester,Minnesota 55905,USA
国际会议
5th East-Asian Polymer Conference(第5届东亚高分子学术研讨会)
上海
英文
20-21
2008-06-03（万方平台首次上网日期，不代表论文的发表时间）