Intramolecular Hydrogen-Bond Switching Triggered by the Side Chain Conformation A Unique Mechanism Involved in the Screw-Sense Inversion of α-Helical Polyaspartates

摘要：

Poly(L-aspartic and ester)s are known to be a versatile system that may form an α-helix in either the right-(R-form) or left-handed screw (L-form) depending on the chemical constitution of the ester group (X) in the sidechain 1,2. While poly(β-benzyl L-aspartate) (X = -CH2φ: PBLA) remains in the L-form in conventionalhelicoidal solution at all temperatures, poly(β-phenethyl L-aspartate) (X = -CH2CH2φ: PPLA) exhibitstransformation from the R-to L-form with increasingtemperature. In this work, copolymers of BLA andPLA have provided a good insight regarding theconformational diversity of polyaspartates. In Fig. 1,conformational transitions observed for PPLAunder various conditions are illustrated, which includetwo helix-coil and two helix-helix transitions.

作者: Akihiro Abe Hidemine Furuya Toshihiro Hiejima

作者单位: Department of Applied Chemistry,Tokyo Polytechnic University,1583 Iiyama,Atsugi 243-0297,Japan Department of Organic and Polymeric Materials,Tokyo Institute of Technology,2-12-1-H-128 Ookayama,Me

会议类型: 国际会议

会议名称: 5th East-Asian Polymer Conference(第5届东亚高分子学术研讨会)

会议地点: 上海

会议语种:英文

页码: 3-4

在线出版日期: 2008-06-03（万方平台首次上网日期，不代表论文的发表时间）