AMPHIPHILIC TRIBLOCK COPLOYMER CARRYING HYPERBRANCHED POLYCARBOSILANE AND β-CYCLODEXTRIN AS PENDENT GROUPS:SYNTHESIS AND CHARACTERIZATION
IntroductionA novel amphiphilic triblock copolymer carrying hyperbranched polycarbosilane and β-cyclodextrin (β-CD)as pendent groups, containing two kinds of cavities for a possible application in the complex drugs delivery system, was designed and synthesized via reversible addition-fragmentation transfer (RAFT) polymerization,acyl reaction, hydrosilylation reaction and immobilization reaction of iodide substituted β-CD (mono-6-I-β-CD).It was known that one kind of cavities in this polymer is from cyclodextrins inherent hydrophobic internal hole and the other is from hyperbranched polymers unique molecular structure. With this distinct character, the drugs with different therapeutic effects can be included into the polymer according to the drugs molecular structure and the different polymer/drugs interactions.
W.Tian X.D.Fan G.Yang
Department of Applied Chemistry,School of Science,Northwestern Polytechnical University,127 Youyi Xilu,Xian,710072,Shanxi,P.R.China
国际会议
5th International Symposium on High-Tech Polymer Materials(HTPM-V)(第五届国际高技术高分子材料学术会议)
北京
英文
229-230
2008-10-27（万方平台首次上网日期，不代表论文的发表时间）