Construction of Functional Poly(aroyl)triazoles by Click Polymerization
1,3-dipolar cycloaddition between azide and acetylene, reviewed systematically by Huisgen in 1980s, was revived after Sharpless and Meldals research groups independently reported that Cu(Ⅰ) species can efficiently catalyze such reaction to obtain regioregular 1,4-disubstituted 1,2,3-triazoles with high yield and simply isolation of products.This react was thus coined as Click Chemistry by Sharpless.It enjoys the features of high yield, mild reaction conditions, and simple product isolation and regioselectivity, thus aroused much interesting among researches.A number of click reactions have been explored and identified, with the metal-catalyzed Huisgens azide-alkyne eyeloaddition being hailed as the cream of the crop. The Cu(Ⅰ)-and Ru(Ⅱ)-mediated 1,3-dipolar cycloadditions proceed steadily, affording 1,4-and 1,5-disubstituted 1,2,3-triazoles,respectively, in high yields.The click chemistry has been utilized to synthesize bioconjugates because the reactants (acetylenes and azides) and the products (triazoles) are all biocompatible. Polymer chemists have employed click chemistry to construct dendritic and linear maeromolecules. The preparations of dendritic polymers, however, require multistep reactions and tedious product isolations, whereas long reaction times and poor product solubility are the big obstacles in the synthesis of linear polymers via the click reaction route.
Anjun Qin Ben Zhong Tang
Department of Polymer Science and Engineering,Zhejiang University,Hangzhou 310027,China;Department of Chemistry,The Hong Kong University of Science & Technology,Clear Water Bay,Kowloon,Hong Kong,China
国际会议
5th International Symposium on High-Tech Polymer Materials(HTPM-V)(第五届国际高技术高分子材料学术会议)
北京
英文
82-83
2008-10-27（万方平台首次上网日期，不代表论文的发表时间）