SYNTHESIS OF FATTY ACID BASED HYPERBRANCHED POLYMERS AND APPLICATION IN DRUG DELIVERY

摘要：

Hyperbranched polymers are recently preferred in drug delivery due to several advantages like multiple sites of attachment, defined size, and controllable physical and chemical properties 1. In this study ricinoleic acid based hyperbranched resin polymers (HBR) were synthesized and characterized for anti-cancer drug delivery. Tamoxifen and idarubicin were loaded to the HBR nanoparticles, drug release profiles were determined and biodegradation of these polymeric nanoparticles were studied. The effect of drug loaded nanoparticles over breast cancer cells were determined by cytotoxicity tests. These results indicated the efficiency of the HBR polymers in controlled drug delivery.

作者: Esra G(UC) Güng(o)r G(U)ND(U)Z Ufuk G(U)ND(U)Z

作者单位: Middle East Technical University,Department of Biological Sciences,Ankara Turkey Middle East Technical University,Department of Chemical Engineering,Ankara Turkey

会议类型: 国际会议

会议名称: 5th International Symposium on High-Tech Polymer Materials(HTPM-V)(第五届国际高技术高分子材料学术会议)

会议地点: 北京

会议语种:英文

页码: 73-74

在线出版日期: 2008-10-27（万方平台首次上网日期，不代表论文的发表时间）