DEVELOPMENT OF MULTI-DRUG DELIVERY SYSTEM BASED ON THE ELECTROSPUN NANO/MICROFIBER MESH TECHNOLOGY
Controlled administration of drugs and/or cytokines based on the well-designed drug delivery system (DDS) is one of the most promising approaches not only for effective cure of various diseases but also for regenerative tissue engineering. In many cases of the practical clinical therapies such as cancer chemotherapy, multiple drugs are concomitantly used aiming for the appropriate expression of their synergic effect, where locally-targeted and timing-regulated administration of multiple drugs are essential issue. For this issue, formulation of a packaged substrate for controlled release of multiple drugs, i.e., multi-drug delivery system (MDDS), is strongly required.In this study, to develop the MDDS substrate which enables the sustained release of multi-drugs with precisely predetermined order, timing and concentration-time pattern, we constructed the multilayered biodegradable nano/microfiber mesh sheet containing different drugs employing multilayering electrospinning (ELSP) that we previously established, designed its structure such as fiber diameter and mesh thickness, and investigated the regulation of drug release property.
Kengo Tominaga Tatsuya Okuda Satoru Kidoaki
Division of Biomolecular Chemistry,Institute for Materials and Engineering,Kyushu University,Fukuoka 819-0395,Japan
国际会议
5th International Symposium on High-Tech Polymer Materials(HTPM-V)(第五届国际高技术高分子材料学术会议)
北京
英文
49-50
2008-10-27（万方平台首次上网日期，不代表论文的发表时间）