Well-Defined (N-Hydroxysuccinimide Methacrylate)-Based Polymeric Materials and Nanoparticles.
A vastly improved polymerization ofN-hydroxysuccinimide methacrylate (MASI) via ATRP is described.Very well-controlled ATRP of MASI is achieved with a combination of a Schiff base ligand N-benzyl-2-pyridylmethanimine (NBPM) and CuCI as catalyst. Although the ATRP of MASI has improved in recent years, yielding polymers of reasonably low PDi (1.15-1.18), the problems of low monomer％conversion and relatively poor first order kinetics remain. The present study using CuCl/NBPM (molar ratio 1:2) and ethyl 2-bromoisobutyrate (EBrIB) as initiator has overcome such shortcomings, presenting optimum conditions for the controlled polymerization of MASI. Poly(MASI) of low PDI (1.10) and high ％conversion (90％) with molar masses up to 19,000 were obtained. Linear first-order kinetics up to 80％ conversion was observed. The end group of the polymer remained active as demonstrated from the successful block copolymerization with 2-(dimethylamino)ethyl methacrylate (DMAEMA) (Scheme 1).Poly(MASI-b-DMAEMA) is water soluble if the chain length of the MASI is relatively short. The block copolymer self-assembled into simple core-shell micelles where the MASI core could be immobilized via crosslinking, generating water-soluble nanoparticles.
L.H.Gan B.W.Mao X.S.Li Y.Y.Gan
Natural Sciences and Science Education,National Institute of Education,Nanyang Technological University,l Nanyang Walk,Singapore 637616,Republic of Singapore
国际会议
5th International Symposium on High-Tech Polymer Materials(HTPM-V)(第五届国际高技术高分子材料学术会议)
北京
英文
32-33
2008-10-27（万方平台首次上网日期，不代表论文的发表时间）