FAST MICROWAVE-MEDIATED EMULSION POLYMERIZATION OF SPIROPYRAN-CONTAINING MONOMERS IN POLYMERIZATION-INDUCED THERMOSENSITIVE MICELLES
20-500 nm diameter polymer nanoparticles containing spiropyran (SP) have been prepared by microwave-mediated emulsion polymerization. This method produces the polymer nanoparticles with tunable size and narrow size distribution. Microwave-mediated emulsion polymerization is conducted in much shorter time than conventional heating bath at rather low temperature between 40-90℃, which provides a promising potential in industrial application. The microwave-mediated emulsion polymerization of styrene with photoswitchable monomer containing SP produced fluorescence-switchable polymer nanoparticles. The prepared nanoparticles could be lighted up affording red fluorescence in the merocyanine (MC) forms of the encapsulated molecules under the irradiation of UV light. Spiro-mero photoisomerization is reversible, allowing the fluorescence to be switched on and off by alternating UV and visible light. Optimalization of polymerization conditions has been investigated allowing for the best optical properties of nanoparticles. An altemating 780 nm NIR laser two-photon excitation/488 nm laser single-photon excitation induces reversible fluorescence of photoswitchable nanoparticles in terms of targeted cells, such as the SK-BR-3 cell line.
Ming-Qiang Zhu Jing Cui Jun-Bing Fan Xiao-Bo Xu Zhi-Wu Liang
Biomedical Engineering Center;State Key Laboratory of Chemo/Biosensing and Chemometrics,Hunan Univer School of Chemistry and Chemical Engineering
国际会议
5th International Symposium on High-Tech Polymer Materials(HTPM-V)(第五届国际高技术高分子材料学术会议)
北京
英文
23
2008-10-27（万方平台首次上网日期，不代表论文的发表时间）