Recent Developments of Platinum-based Anti-tumor Compounds

摘要：

Platinum-based drugs are among the most effective anti-tumor agents, however the clinical use is frequently limited by severe toxic side-effects such as nephrotoxicity, neurotoxicity and meylosuppression as well as drug resistance. Therefore, the search for the new potent platinum complexes possessing high anti-tumor activity, low toxicity and lack of cress-resistance is continuing. As an important research field of Kunming Institute of Precious Metals, our research team has recently made some progress in design and synthesis of novel anti-tumor platinum compounds including water soluble antitumor platinum compounds, lipophilic anti-tumor platinum compounds and anti-tumor platinum compounds with less-croes resistance. In the present paper, we will introduce our recent progress in this field.

关键词： Platinum Anti-tumor Design Synthesis

作者: Liu Weiping Hou Shuqian

作者单位: Kunming Institute of Precious Metals,Kunming 650221,China

会议类型: 国际会议

会议名称: 第三届国际贵金属会议(The Third International Conference on Precious Metals)

会议地点: 西安

会议语种:英文

页码: 246-255

在线出版日期: 2008-06-01（万方平台首次上网日期，不代表论文的发表时间）