Towards a Medium/High Load-bearing Scaffold Fabrication System
(0) Fused Deposition Modeling (FDM) is a leading commercial process for developing 3D objects by extrusion of semi-molten filament material. Variations of this process have been used to develop scaffold structures that can eventually lead to treatment of bone fractures and trauma-related injuries. Such injuries account for over 1.3 million surgical procedures a year in the United States alone (Langer and Vacanti 1993).However, such scaffolds cannot currently provide solutions for all these potential cases. Continuous process improvement and understanding of parameters is necessary to achieve scaffolds with suitable mechanical properties to aid in repair/regeneration of bone defects, particularly for medium/high load bearing applications.In spite of exploring a large variety of biomaterials and fabrication techniques in the last two decades, bone tissue engineering structures have been used with successes for minimal load-bearing applications only.This paper describes work carried out by the authors; focusing on fabrication of scaffolds for load-bearing applications, with primary consideration from the manufacturing perspective. An extrusion device, inspired by the FDM process, is used to create scaffolds from a variety of different polymeric materials and mixtures.The effectiveness of these scaffolds to host cells for bone regeneration has also been investigated and will be reported on. This ongoing work has generated significant insight into the future direction of research and the possibilities of developing scaffolds for medium/high load-bearing applications.
Ian GIBSON Monica M SAVALANI Christopher XF LAM Radoslaw OLKOWSKI Andrew K EKAPUTRA Kim Ching TAN Dietmar W HUTMACHER
Department of Mechanical Engineering, National University of Singapore, Singapore
国际会议
北京
英文
158-165
2008-11-06（万方平台首次上网日期，不代表论文的发表时间）