On Modeling Bio-Scaffolds: structural and fluid transport characterization based on 3D imaging data
Bio-scaffolds which are most commonly open celled porous structures are increasingly used for tissue engineering and regenerative medicine. Numerical studies exploring the influence of architecture on structural and flow characteristics of porous media have been carried out but these studies almost exclusively assume an idealized repeating unit cell approach. However, most of the traditional techniques employed to manufacture bio-scaffolds do not result in uniform pore sizes and connectivities. A number of studies have shown that the bulk properties of such irregular structures are poorly modeled using idealized unit cell approaches. Even the periodic cell unit structures made by emerging rapid prototyping techniques would became irregular in vitro and in vivo environments as cell ingrowths and tissue formation progressed. Therefore, accurate modeling of bio-scaffolds with non-uniform cellular structures is very important for the development of optimal scaffolds for tissue engineering application. A number of studies will be shown which demonstrate the ease with which fidelic models of the complex micro-architectures of bio-scaffolds can be generated. In addition, studies will be presented which explore both fluid flow and bulk structural properties of a range of bio-scaffolds.
Bio-scaffolds material characterization finite element computational fluid Dynamics Microstructures
NOTARBERARDINO Bruno YOUNG Philippe BAKER Matthew TABOR Gavin HAO Liang TURNER Irene YANG Lincoln
School of Engineering, Computing and Mathematics, University of Exeter, United Kingdom Department of Mechanical Engineering, University of Bath, United Kingdom Shanghai Gaitech Scientific Instruments Co., Ltd., Shanghai, China
国际会议
北京
英文
131-134
2008-11-06（万方平台首次上网日期，不代表论文的发表时间）