A novel osteochondral scaffold with a compact layer fabricated via multi-nozzle low-temperature deposition manufacturing
A functional-region/separate-interface/single-cell-type tissue engineering pathway was proposed to supply a promising approach to regenerate osteochondral defects that are deep to marrow cavity. A gradient osteochondral scaffold fabricated via a rapid prototyping technology called multi-nozzle low-temperature deposition manufacturing was composed of three parts with different materials and pore-structures respectively for bone, cartilage and a separate interface between them. The separate interface is composed of micro-pores less than 5 m μ and with low porosity. Therefore it could reduce or avoid destroying the micro-environment in vivo by preventing the blood and cells and reducing the amount of oxygen and nutrition getting from marrow cavity to articulate marrow. The preliminary results from 6 weeks implantation into 4mm diameter osteochondral defects in the knee joints of rabbits show that the defects with the scaffold/cells composition (experiment group) revealed bone-like or cartilage-like tissues filling the defects with smooth surface, while the defects with nothing (blank group) showed only fibrous tissues.
tissue engineering rapid prototyping osteochondral separate interface low-temperature Deposition
Li Liu Zhuo Xiong Renji Zhang Le Jin Yongnian Yan
Department of Mechanical Engineering, Tsinghua University, Key Laboratory for Advanced Materials Processing Technology Ministry of Education, P.R.China, Beijing 100084
国际会议
北京
英文
96-102
2008-11-06（万方平台首次上网日期，不代表论文的发表时间）