The Bioinformatics Analysis of Hepatitis C Virus E2 Protein

摘要：

By the methods of bioinformatics, the sequences of HCV E2 protein from all the genotypes are studied on the variation and the B-cell epitopes. We find that even in the HVR1 and HVR2 regions, there are also some conservative sites, such as T2, G6, G23, and Q26, all of which belong to polar R-base amino acids without charge, and can lost proton to conform hydrogen bond. Meanwhile, we find the conservative amino acids locate on the surface of E2 protein, make up of |? -turn and B-cell epitopes. This will contribute to prompt the development of HCV vaccine.

关键词： Hepatitis C Virus Bioinformatics E2 protein Epitopes Conservative sites

作者: Tailin Guo Shuhui Wang Yihong Wu

作者单位: School of Bioengineering, Southwest Jiaotong University, Chengdu 610031, China

会议类型: 国际会议

会议名称: The 2007 International Conference on Intelligent Systems and Knowledge Engineering(第二届智能系统与知识工程国际会议)

会议地点: 成都

会议语种:英文

页码: 172-177

在线出版日期: 2007-10-15（万方平台首次上网日期，不代表论文的发表时间）