Microparticles Generated from Melted Tripalmitin Using Supercritical Fluids
(0) The supercritical N2-assisted atomization (SNA) process and the supercritical CO2-assisted atomization (SCA) process for generating particle from melted tripalmitin were experimentally studied by using a technique similar to the process of particle formation from gas-saturated solutions. The effects of various operating conditions, including the pre-expansion pressure, pre-expansion temperature, and nozzle diameter on the particle morphology, particle size and particle size distribution (PSD) were investigated. Results showed that both the SNA and the SCA processes could generate nano- and micro-lipid particles under the investigated conditions. Spherical particles were produced from the SNA process, while spherical, lamellate and needle-like particles were obtained from the SCA process. For the two processes, the particle size decreases and PSD narrows with the increasing of the pre-expansion pressure; no obvious effect could be observed from the variation of nozzle diameter. The particles produced from SNA, SCA and RESS were compared based on the X-ray diffraction (XRD) analyses. It is concluded that the SNA technique could be used to produce particles with uniform morphology due to the solidification process through atomization. Yet, the SCA technique could produce nano- and micro- particles with different morphologies due to both crystallization and atomization mechanisms.
osupercritical fluids CO2 N2 tripalmitin micronization melt
Yanni Guo Xia Wang Yanzhen Hong Yuzhong Su Hongtao Wang Jun Li
Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, P.R.China
国际会议
The 12th Asian Pacific Confederation of Chemical Engineering Congress(第十二届亚太化工联盟大会暨化工展览会)
大连
英文
2008-08-04（万方平台首次上网日期，不代表论文的发表时间）