Water Dosing Effect on Erythromycin Solventing-out Process Measured by Focused Beam Reflective Measurement Technology
Erythromycin solventing-out process can be affected by many factors such as temperature, solvent, as well as water dosing rate. This paper studies the water dosing effect on erythromycin solventing out process measured by focused beam reflective measurement (FBRM) technology. Subsequent result shows this technique can give a detailed picture on the particle size distribution, which is a corrected result of chord length distribution with an interval as short as two seconds. The FBRM technology thus can guide and boost industrial practice for better efficacy, unity and particle size distribution in pharmaceutical crystals.
Erythromycin FBRM Solventing out Particle size distribution
Chen Kui Cao Bing Zhu Jiawen Wu Bin Ji Lijun
School of Chemical Engineering, East China University of Science and Technology, Shanghai, 200237
国际会议
The 12th Asian Pacific Confederation of Chemical Engineering Congress(第十二届亚太化工联盟大会暨化工展览会)
大连
英文
2008-08-04（万方平台首次上网日期，不代表论文的发表时间）