Electrospinning of Emulsion Nanofibers Containing Sorbitan Monooleate and Poly (L-Lactide-co-ε-Caprolactone) for Growing Pig Iliac Endothelium Cells
The aim of this study was to investigate electrospinning of emulsions to prepare biodegradable nanofibrous mats for being an innovative type of cell-growth scaffolds with potentially controllable drug releasing capabilities. The hypothesis was that the Poly (L-Lactide-co-ε -Caprolactone) P(LLA-CL) nanofibrous mats containing Sorbitan Monooleate (Span-80) could be appropriate scaffolds for growing pig iliac endothelium cells (PIECs). To test the hypothesis, the electrospinning of emulsions made of P(LLA-CL), chloroform, Span-80, and distilled water to prepare P(LLA-CL)/Span-80 nanofibrous mats was systematically investigated. The effects of water content and P(LLA-CL) concentration in the emulsions on the morphologies of the nanofibers were studied. The morphologies of nanofibrous mats were examined by a Scanning Electron Microscopy (SEM); and the performance for being scaffolds was investigated by examination of the viability (anchorage and proliferation) and morphology of PIECs on the nanofibrous mats. The results indicated that the incorporation of Span-80 into P(LLA-CL) nanofibers did not have any negative effect on the growth of PIECs; and the P(LLA-CL)/Span-80 nanofibrous mats could be used as an innovative type of scaffolds with potentially controllable drug releasing capabilities.
Electrospinning Drug Delivery Biocompatibility Nanofibers
Li Xiaoqiang Su Yan He Chuanglong Wang Hongsheng Mo Xiumei
Key Laboratory of Science & Technology of Eco-Textile Donghua University,Ministry of Education, Chin Institute of Biology Science and Biotechnology, Donghua University, Shanghai,201620, China
国际会议
The 12th Asian Pacific Confederation of Chemical Engineering Congress(第十二届亚太化工联盟大会暨化工展览会)
大连
英文
2008-08-04（万方平台首次上网日期，不代表论文的发表时间）