Mathematical Analysis of An Modified Immune HBV Model

摘要：

Mathematical models have been used to understand the factors that govern infectious disease progression in viral infections.Immune responses,especially cytotoxic T limpocyte (CTL)responses,play an important role in determining whether infections will be cleared or become persistent.Many HBV immune model were based on the basic virus infection model (BVIM)introduced by Zeuzem et al.and Nowak et al.But we have pointed out that the basic infection reproductive number of BVIM may be modified,so the correlative immune models could be also modified.In this paper,we introduce an modified immune model about CTL response to HBV.The corresponding reproductive number seems more reasonable,and the theoretical analysis shows that the CTL response increases the equilibrium abundance of uninfected cells and reduces the equilibrium abundance of infected cells and free virus,which seems also reasonable.

关键词： mathematical model HBV immune dynamic behaviour

作者: Yongmei Su Lequan Min Xijian Zhuo

作者单位: School of Applied Science of University of Science and Technology Beijing, Beijing 100083,China School of Information Engineering of Beijing University of posts and telecommunications,Beijing 1008

会议类型: 国际会议

会议名称: 中国数学会生物数学分会第六届学术年会

会议地点: 山东泰安

会议语种:英文

页码: 541-545

在线出版日期: 2008-07-25（万方平台首次上网日期，不代表论文的发表时间）