THE PROGRESSION OF TUMOR CELL NUCLEAR TRANSFER
In the end of 1960s, the first researchers used frog kidney cancer cell as donor, and then transferred it into the oocyte cytoplasm. As a result, it reversed the tumor formation and the reprogrammed cell developed to the tadpole stage(McKinnell, R.G.et al, 1969). Modlinski etc(1990) isolated mouse embryonic tumor cell which was then transferred into the mouce oocyte cytoplasm in vitro using nuclear transfer technology. After 22h cultivation, they found that embryonic tumor cell show their reshape characteristics, and only a few of them could develop to blastula. Li etc(2003) used medulloblastoma cell nucleus as donor to perform tumor cell nuclear transfer(TCNT) and it come out that they can develop to blastula.
Hailong Wang Xin Huang
The medical college, Xiamen University, Xiamen city, Fujian, 361005, China
国际会议
The 5th Annual Conference of the Asian Reproductive Biotechnology Society(第五届亚洲动物繁殖生物技术大会)
昆明
英文
164
2008-11-26（万方平台首次上网日期，不代表论文的发表时间）